Maintenance Dose Calculator
Calculate the ideal maintenance dose for medications based on pharmacokinetic parameters: desired concentration, clearance, bioavailability, and dosing interval. Essential for clinicians and pharmacy professionals.
Step 1: Drug & PK
Understanding PK parameters
Desired concentration (Css): target therapeutic level. Clearance (CL): volume of plasma cleared of drug per time. Bioavailability (F): fraction of dose reaching systemic circulation. These determine the maintenance dose.
Step 2: Regimen & patient
Dosing tips
The maintenance dose keeps drug concentration within therapeutic window. Adjust interval based on half‑life. Always consider individual patient factors.
Maintenance Dose Results
Maintenance dose per administration
Dose comparison for different drugs
| Drug / Scenario | Assumed CL (L/hr) | Bioavail. (F) | Dose per interval |
|---|
Daily dose by drug category
Maintenance dose formula
Dose = (Css × CL × τ) / F
where τ = dosing interval. This gives the amount per administration. Multiply by (24/τ) for daily dose. Always verify with clinical guidelines.
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